What is the expansion of EDTA?

Ethylenediamine tetraacetic acid (EDTA) is a polyprotic acid containing four carboxylic acid groups and two amine groups with lone-pair electrons that chelate calcium and several other metal ions.

1. What is EDTA in chemistry?
2. What does EDTA blood stand for?
3. What is EDTA anticoagulant?
4. What is EDTA tube used for?
5. What is EDTA in microbiology?
6. What is the function of heparin?
7. How does heparin prevent clotting?
8. What is the difference between EDTA and heparin?
9. Why EDTA is added to plasma?
10. How does EDTA work as anticoagulant?
11. What is EDTA induced platelet clumping?
12. What is EDTA and give its importance?
13. How does EDTA prevent blood clotting?

What is EDTA in chemistry?

A chemical that binds certain metal ions, such as calcium, magnesium, lead, and iron. It is used in medicine to prevent blood samples from clotting and to remove calcium and lead from the body. Also called edetic acid and etheylenediaminetetraacetic acid. ...

What does EDTA blood stand for?

EDTA stands for Ethylenediaminetetraacetic acid. EDTA functions by binding calcium in the blood and keeping the blood from clotting.

What is EDTA anticoagulant?

Ethylenediaminetetraacetic acid (EDTA) is a well-known anticoagulant since early 1950s and it has certain advantages over other anticoagulants [2]. It inhibits clotting by removing or chelating calcium from the blood.

What is EDTA tube used for?

Routine hematology tests require a blood collection tube containing EDTA, a chelating anticoagulant. EDTA preserves the morphology of the cellular elements of blood, making it a satisfactory anticoagulant for hematologic studies.

What is EDTA in microbiology?

Ethylenediaminetetraacetic acid (EDTA) is a well known metal-chelating agent, extensively used for the treatment of patients who have been poisoned with heavy metal ions such as mercury and lead.

What is the function of heparin?

Heparin injection is an anticoagulant. It is used to decrease the clotting ability of the blood and help prevent harmful clots from forming in blood vessels. This medicine is sometimes called a blood thinner, although it does not actually thin the blood.

How does heparin prevent clotting?

Once active thrombosis has developed, larger amounts of heparin can inhibit further coagulation by inactivating thrombin and preventing the conversion of fibrinogen to fibrin. Heparin also prevents the formation of a stable fibrin clot by inhibiting the activation of the fibrin stabilizing factor.

What is the difference between EDTA and heparin?

EDTA and citrate remove calcium, which most coagulation factors need. Heparin activates antithrombin thereby inhibiting coagulation by inhibiting thrombin. ... Heparin is used for clinical chemistry tests such as cholesterol, CRP, hormones etc. It interferes with PCR, so if you want to do that use EDTA.

Why EDTA is added to plasma?

Ca²⁺ is an essential part of the prothrombinase complex as an initiator of coagulation and consequently the clotting process is prevented in EDTA plasma [2]. An advantage with this anticoagulant is its capability of not distorting blood cells, which makes it ideal for hematology studies and DNA extraction.

How does EDTA work as anticoagulant?

Ethylenediaminetetraacetic acid (EDTA) strongly and irreversibly chelates (binds) calcium ions, preventing blood from clotting. ... Correct proportion of this anticoagulant to blood is crucial because of the dilution, and it can be reversed with the addition of calcium.

What is EDTA induced platelet clumping?

DISCUSSION. EDTA-dependent PTCP is the phenomenon of a spurious low platelet count due to the appearance of antiplatelet autoantibodies that cause platelet clumping in blood anticoagulated with EDTA^5,6).

What is EDTA and give its importance?

A specific salt of EDTA, known as sodium calcium edetate, is used to bind metal ions in the practice of chelation therapy, such as for treating mercury and lead poisoning. It is used in a similar manner to remove excess iron from the body. ... EDTA is used extensively in the analysis of blood.

How does EDTA prevent blood clotting?

With the correct blood sampling procedure, the collected blood is exposed to the EDTA which binds and withholds calcium ions thereby blocking the activation or progression of the coagulation cascade – ultimately inhibiting clot formation.